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Search Results for " hmg-coa reductase-in-1 "

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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T79520	HMG-CoA Reductase-IN-1
	HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂，显示出高HMGR抑制活性及OATP1B1亲和力，具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。
T81257	Rosuvastatin zinc salt Rosuvastatin zinc
	Rosuvastatin zinc salt (Rosuvastatin zinc)，为Rosuvastatin的含锌盐形态，属于HMG-CoA还原酶抑制剂类药物，常用于动脉粥样硬化的研究领域。
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
T35718	N-desmethyl Rosuvastatin (sodium salt hydrate)
	N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand...

化合物

HMG-CoA Reductase-IN-1

Cat.No: T79520

Rosuvastatin zinc salt

Cat.No: T81257

Synonym: Rosuvastatin zinc

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

N-desmethyl Rosuvastatin (sodium salt hydrate)

Cat.No: T35718

Cat. No.	Product Name	Target	Signaling Pathways
T35400	β-Muricholic Acid β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
	β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

天然产物

β-Muricholic Acid

Cat.No: T35400

Synonym: β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid

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