Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2674 |
GSK0660
|
PPAR | DNA Damage/DNA Repair; Metabolism |
GSK0660 是 PPARβ/δ 的拮抗剂和反向激动剂,IC50均为155 nM。 | |||
T70886 | PT-S58 | ||
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. PT-S58 are effective on PPRE-independent functions of PPARβ/δ. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT. |