Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00176 |
FNDC4 Protein, Human, Recombinant (mFc)
fibronectin type III domain containing 4,FRCP1<... |
Human | HEK293 Cells |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, trea... |