Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1923 |
Elabela(19-32)
ELA-14 (human) |
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Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo. | |||
T76044 |
Elabela(19-32) TFA
|
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Elabela(19-32) TFA 是ELABELA(ELA)与apelin受体(APJ)结合的活性片段,能激活Gαi1和β-arrestin-2信号通路,EC50值分别为8.6 nM和166 nM。该化合物可诱导受体内在化,降低动脉压,并对心脏具有正性肌力作用。 |