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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
TP2098 Echistatin

Echistatin, α1 isoform

Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3)

化合物

Echistatin
Cat.No: TP2098
Synonym: Echistatin, α1 isoform
Target:
Cat. No. Product Name Target Signaling Pathways
T36295 Echistatin TFA

Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Echistatin TFA
Cat.No: T36295
Synonym:
Target:
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