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Search Results for " epd "

Targets Recommended: Antibiotic

14

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11815	Lanopepden GSK 1322322,GSK-1322322B,GSK-1322322J	Antibiotic	Microbiology/Virology
	Lanopepden (GSK 1322322) 是一种有效的肽去甲酰酶抑制剂，抑制金黄色葡萄球菌，抑制 ATCC 29213 和 ATCC 25923 菌株，可用于研究肺炎、皮肤病和传染病。
T71699	Lanopepden mesylate GSK 1322322 mesylate,GSK-1322322J mesylate	Antibacterial	Microbiology/Virology
	Lanopepden mesylate 是一种肽去甲酰酶抑制剂，可抑制金黄色葡萄球菌。
T37235	(±)16(17)-EpDPA (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahex...
T37239	(±)19(20)-EpDTE
	(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase.
T37241	(±)4(5)-EpDPA methyl ester
	(±)4(5)-EpDPA methyl ester is a derivative of (±)4(5)-EpDPA which is stable enough to ship and handle routinely. The active free acid can be regenerated from the methyl ester by careful base hydrolysis. (±)4(5)EpDPA is a CYP450 metabolite of DHA which can be further metabolized to the diol metabolite. There are no published reports on the biological activity of (±)4(5)-EpDPA methyl ester at this time.
T35493	(±)10(11)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 μM. (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in infla...
T36218	19R(20S)-EpDPA
	19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.219R(20S)-EpDPA (30 nM) prevents calcium-induced increases in the spontaneous beating of isolated neonatal rat cardiomyocytes (NRCMs).3 1.Cinelli, M.A., Yang, J., Scharmen, A., et al.Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acidsJ. Lipid Res.59(11)2237-2252(2018) 2.Lucas...
T76256	Erepdekinra
	Erepdekinra 是一种白细胞介素-17A (IL-17A) 受体拮抗剂。
T35496	(±)13(14)-EpDPA
	Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy m...
T37226	(±)7(8)-EpDTE
	(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase.
TP1128	Ac-IEPD-AFC IEPD
	Ac-IEPD-AFC (IEPD) is a substrate of Granzyme B.
T35497	(±)7(8)-EpDPA
	Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting ...
T37238	(±)19(20)-EpDPA
	EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic...
T70642	Lanopepden camsylate
	Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea...

化合物

Cat.No: T11815

Synonym: GSK 1322322,GSK-1322322B,GSK-1322322J

Target: Antibiotic

Lanopepden mesylate

Cat.No: T71699

Synonym: GSK 1322322 mesylate,GSK-1322322J mesylate

Target: Antibacterial

(±)16(17)-EpDPA

Cat.No: T37235

Synonym: (±)16,17-EpDPE,(±)16,17 EDP,(±)16,17-epoxy Docosapentaenoic Acid,(±)16,17-epoxy DPA,(±)16(17)-EpDPA

(±)19(20)-EpDTE

Cat.No: T37239

(±)4(5)-EpDPA methyl ester

Cat.No: T37241

(±)10(11)-EpDPA

Cat.No: T35493

19R(20S)-EpDPA

Cat.No: T36218

Cat.No: T76256

(±)13(14)-EpDPA

Cat.No: T35496

(±)7(8)-EpDTE

Cat.No: T37226

Cat.No: TP1128

Synonym: IEPD

(±)7(8)-EpDPA

Cat.No: T35497

(±)19(20)-EpDPA

Cat.No: T37238

Lanopepden camsylate

Cat.No: T70642

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01588	ALDH7A1 Protein, Human, Recombinant (His) ATQ1,aldehyde dehydrogenase 7 family, member A1,EPD...	Human	E. coli
	ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine...
TMPY-00725	COMP Protein, Human, Recombinant (His) THBS5,MED,EPD1,PSACH,cartilage oligomeric matrix pr...	Human	HEK293 Cells
	Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and functio...
TMPY-03598	EPDR1 Protein, Human, Recombinant (His) ependymin related 1,MERP1,UCC1,MERP-1,EPDR	Human	HEK293 Cells
	EPDR1 is a member of the ependymin family. EPDR1 is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. It may play a role in calcium-dependent cell adhesion. EPDR1 is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
TMPJ-00540	PEPD Protein, Human, Recombinant PRD,Imidodipeptidase,PEPD,PeptidaseD,Prolinedipepti...	Human	E. coli
	PEPD belongs to the peptidase M24B family of Eukaryotic-type prolidase subfamily. PEPD is a cytosolic dipeptidase that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy terminus. It is important in collagen metabolism because of the high levels of imino acids. Defects in PEPD are a cause of prolidase deficiency which is an autosomal recessive disorder associated with iminodipeptiduria.

重组蛋白

ALDH7A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01588

Species: Human

Expression System: E. coli

COMP Protein, Human, Recombinant (His)

Cat.No: TMPY-00725

Species: Human

Expression System: HEK293 Cells

EPDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03598

Species: Human

Expression System: HEK293 Cells

PEPD Protein, Human, Recombinant

Cat.No: TMPJ-00540

Species: Human

Expression System: E. coli

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