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Cat. No. | Product Name | Target | Signaling Pathways |
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T68151 |
Tallimustine
FCE 24517 |
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Tallimustine (FCE 24517),一种 distamycin-A 衍生物,是一种抗癌剂。 | |||
T69978 |
Brostallicin HCl
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Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T73730 |
Distamycin A
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Distamycin A (NSC-82150)为一种寡肽抗生素及小沟结合剂,其结合B型DNA,并倾向于A/T富集区。Distamycin A能调节烯二炔诱导DNA切割位点并促进细胞凋亡。 |