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Cat. No. Product Name Target Signaling Pathways
T36536 SH-42

SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2
T71133 Azacosterol hydrochloride

Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone pr...

化合物

SH-42
Cat.No: T36536
Synonym:
Target:
Azacosterol hydrochloride
Cat.No: T71133
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T19711 Desmosterol

Desmesterol,24-Dehydrocholesterol

Endogenous Metabolite Metabolism
Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体,抑制巨噬细胞炎症小体活化,防止血管炎症和动脉粥样硬化。

天然产物

Desmosterol
Cat.No: T19711
Synonym: Desmesterol,24-Dehydrocholesterol
Target: Endogenous Metabolite
TargetMol Loading
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