Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19273 |
Debutyldronedarone D7
SR-35021 D7 |
Others | Others |
Debutyldronedarone D7 is deuterium-labeled Debutyldronedarone, which is the main circulating active metabolite of dronedarone in the body. | |||
T35712 |
Debutyldronedarone hydrochloride
SR35021 hydrochloride |
||
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h... |