Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0389 |
Dabigatran etexilate
达比加群酯,BIBR 1048 |
Thrombin | Proteases/Proteasome |
Dabigatran etexilate (BIBR 1048) 是一种 Dabigatran 前药,具有口服活性。它具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T5133 |
Dabigatran Etexilate Mesylate
甲磺酸达比加群酯,BIBR 1048MS,Dabigatran etexilate methanesulfonate |
Thrombin | Proteases/Proteasome |
Dabigatran Etexilate Mesylate (BIBR 1048MS) 是一种口服具有活性的 Dabigatran 前药,具有抗凝作用,能够预防心房颤动引起的静脉血栓栓塞和中风。 | |||
T19208 |
BIBR 1087 SE
去乙基达比加群酯,Desethyl Dabigatran Etexilate |
Others | Others |
BIBR 1087 SE (Desethyl Dabigatran Etexilate) 是一种 dabigatran etexilate 的代谢物。 | |||
T35939 |
Dabigatran Acyl-β-D-Glucuronide
|
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Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran. |