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Cat. No.	Product Name	Target	Signaling Pathways
T24466	Milademetan free base DS3032B,DS-3032,DS3032,DS 3032,DS 3032B,DS-3032B
	Milademetan (DS-3032b or DS-3032) is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Milademetan (p.o.) binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protei
T28038	Milademetan HCl (1398568-47-2 free base) Milademetan HCl,DS3032,DS 3032,DS-3032,DS3032b,DS-3032b,DS 3032b
	Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apopto...