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Cat. No. | Product Name | Target | Signaling Pathways |
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T81780 |
MMH2
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MMH2作为一种新型BRD4分子胶降解剂,其作用机制基于通过CUL4和DCAF16连接酶复合体的招募,特异性地定位于BRD4的第二个溴结构域(BRD4BD2),进而实现其降解活性。 | |||
T75139 | TMX1 | ||
TMX1 是一种 BRD4共价分子胶降解剂。TMX1 选择性地将 DCAF16 招募到 BRD4BD2 上,导致 BRD4的降解。 | |||
T81781 |
MMH1
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MMH1为一种新型BRD4分子胶降解剂,它主要通过CUL4与DCAF16连接酶复合体直接针对BRD4的第二个溴结构域(BRD4BD2)发挥作用。 | |||
T18060 |
KB02-JQ1
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Others; PROTACs | Others; PROTAC |
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link... | |||
T18061 |
KB02-SLF
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Others; PROTACs | Others; PROTAC |
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1]. |
Cat. No. | Product Name | Species | Expression System |
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TMPH-01203 |
DCAF16 Protein, Human, Recombinant (His & Myc)
C4orf30,DCAF16,DDB1- and CUL4-associated f... |
Human | E. coli |
Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. DCAF16 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q9NXF7. |