Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16898 |
Complement factor D-IN-1
|
Others | Others |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T11269 |
FD-IN-1
|
Others | Others |
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. | |||
T76814 | Lampalizumab | ||
Lampalizumab (RG 7417) 为靶向补体通路中补体因子 D (Factor D) 的人源单克隆抗体。通过结合外位点,该药物立体阻断因子 B 进入活性位点,用于老年性黄斑变性 (AMD) 研究。 | |||
T77219 |
N-((Allyloxy)carbonyl)-N-methyl-L-alanine
|
||
N-((Allyloxy)carbonyl)-N-methyl-L-alanine 是一种丙氨酸衍生物。N-((Allyloxy)carbonyl)-N-methyl-L-alanine 可用于合成补体因子 D (complementfactor D) 抑制剂。补体因子 D 抑制剂可用于免疫系统相关疾病的研究。 |