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2

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T78011	Cyclic MKEY TFA
	Cyclic MKEY TFA为CXCL4-CCL5异二聚体的合成环肽抑制剂，可通过调控炎症反应预防动脉粥样硬化和主动脉瘤。此外，该化合物亦能阻止小鼠中风后脑损伤的发生。
TP1620	Cyclic MKEY
	MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not

化合物

Cyclic MKEY TFA

Cat.No: T78011

Cat.No: TP1620

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00741	CXCL4 Protein, Human, Recombinant PF-4,platelet factor 4,SCYB4,...	Human	E. coli
	Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils a...
TMPK-00012	CXCL4 Protein, Human, Recombinant (His & Avi) PF-4,CXCL4,SCYB4,Oncosta...	Human	E. coli
	Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi) is expresse...
TMPK-01248	CXCL4 Protein, Mouse, Recombinant (hFc) PF-4,CXCL4,SCYB4,Oncosta...	Mouse	HEK293 Cells
	Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Mouse, Recombinant (hFc) is expressed in H...
TMPK-00014	CXCL4 Protein, Human, Recombinant (hFc) Iroplact,CXCL4,Oncostatin-A,PF-4,...	Human	HEK293 Cells
	Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (hFc) is expressed in H...
TMPK-00013	CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated SCYB4,MGC138298,PF-4,Iroplact,Oncostatin-A...	Human	E. coli
	Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylat...
TMPH-03121	CXCL4 Protein, Pig, Recombinant (His & Myc) SCYB4,CXCL4,PF4,Platelet...	Sus scrofa (Pig)	E. coli
	Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. CXCL4 Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.1 kDa and the accession number is P30034.
TMPJ-00012	CXCL4 Protein, Human, Recombinant (His) SCYB4,PF4,Iroplact,Platelet Factor 4	Human	HEK293 Cells
	Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokin...
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...

重组蛋白

CXCL4 Protein, Human, Recombinant

Cat.No: TMPY-00741

Species: Human

Expression System: E. coli

CXCL4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00012

Species: Human

Expression System: E. coli

CXCL4 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01248

Species: Mouse

Expression System: HEK293 Cells

CXCL4 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00014

Species: Human

Expression System: HEK293 Cells

CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00013

Species: Human

Expression System: E. coli

CXCL4 Protein, Pig, Recombinant (His & Myc)

Cat.No: TMPH-03121

Species: Sus scrofa (Pig)

Expression System: E. coli

CXCL4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00012

Species: Human

Expression System: HEK293 Cells

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

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