Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21410 |
Triptorelin acetate(57773-63-4 free base)
醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003 |
GNRH Receptor | GPCR/G Protein |
Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症,如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。 | |||
T71147 | PBS-1086 | ||
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines. |