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Cat. No.	Product Name	Target	Signaling Pathways
T17164	Trimetrexate 三甲曲沙,CI-898	Others	Others
	Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.
T63985	Trimetrexate glucuronate
	Trimetrexate glucuronate (NSC 352122) 是一种叶酸拮抗剂，能够抑制二氢叶酸还原酶 (dihydrofolate reductase)，进而阻断嘌呤核苷酸和胸苷酸的合成，影响 DNA 和 RNA 合成，表现出潜在的抗肿瘤效果。
T70304	CI-898 HCl
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.