Cat. No. | Product Name | Target | Signaling Pathways |
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T70552 |
Ipatasertib tosylate
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Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor... | |||
T70553 |
CCT245737(S)
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CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor. |