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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T72819 UNC6212 (Kme2)

UNC6212 (Kme2),一种含有二甲基赖氨酸 (Kme2) 的配体,与 CBX5 结合的KD 值为 5.7 μM。
T74223 UNC6864 (Kei)

UNC6864 (Kei) 是一种含乙基异丙基赖氨酸 (Kei) 的配体,与野生型 CBX5 结合,结合亲和力 KD 为 3.3 μM。
T74224 UNC6349 (Ket2)

UNC6349 (Ket2),含有二乙基赖氨酸 (Ket2) 的配体,与野生型 CBX5 结合,结合亲和力 KD 为 3.2 μM。

化合物

UNC6212 (Kme2)
Cat.No: T72819
Synonym:
Target:
UNC6864 (Kei)
Cat.No: T74223
Synonym:
Target:
UNC6349 (Ket2)
Cat.No: T74224
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPH-01088 CBX5 Protein, Human, Recombinant (His & Myc)

HP1 alpha,CBX5,Heterochromatin protein 1 h...

Human E. coli
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. CBX5 Protein...
TMPJ-01213 ASXL1 Protein, Human, Recombinant (GST)

Putative Polycomb group protein ASXL1,Additional sex combs-l...

Human E. coli
Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 t...
TMPH-02274 JAK2 Protein, Human, Recombinant (His)

Human E. coli
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int...

重组蛋白

CBX5 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01088
Species: Human
Expression System: E. coli
ASXL1 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01213
Species: Human
Expression System: E. coli
JAK2 Protein, Human, Recombinant (His)
Cat.No: TMPH-02274
Species: Human
Expression System: E. coli
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