3
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72819 | UNC6212 (Kme2) | ||
UNC6212 (Kme2),一种含有二甲基赖氨酸 (Kme2) 的配体,与 CBX5 结合的KD 值为 5.7 μM。 | |||
T74223 | UNC6864 (Kei) | ||
UNC6864 (Kei) 是一种含乙基异丙基赖氨酸 (Kei) 的配体,与野生型 CBX5 结合,结合亲和力 KD 为 3.3 μM。 | |||
T74224 | UNC6349 (Ket2) | ||
UNC6349 (Ket2),含有二乙基赖氨酸 (Ket2) 的配体,与野生型 CBX5 结合,结合亲和力 KD 为 3.2 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01088 |
CBX5 Protein, Human, Recombinant (His & Myc)
HP1 alpha,CBX5,Heterochromatin protein 1 h... |
Human | E. coli |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. CBX5 Protein... | |||
TMPJ-01213 |
ASXL1 Protein, Human, Recombinant (GST)
Putative Polycomb group protein ASXL1,Additional sex combs-l... |
Human | E. coli |
Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 t... | |||
TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... |