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32

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T71799	CAP-1	Others	Others
	CAP-1 is an inhibitor of HIV-1 capsid formation.
T63808	Cap-dependent endonuclease-IN-1	Others	Others
	Cap-dependent endonuclease-IN-1 是一种具有高效性和口服活性的帽依赖内切酶抑制剂，具有抗病毒活性，可用于研究流感病毒感染。
T36451	1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt),biotin-cap-DPPE	Others	Others
	1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used i...
T61757	Cap-dependent endonuclease-IN-26	Others	Others
	Cap-dependent endonuclease-IN-26, a potent inhibitor of cap-dependent endonuclease (CEN) with an IC50 of 286 nM, exhibits significant antiviral activity against a broad spectrum of influenza A and B strains [1].
T74479	m7GpppUpG	Others	Others
	m7GpppUpG，作为一种oligonucleotide，属于M7GpppNpG 三核苷酸帽类似物。该化合物被应用于合成具cap 0或cap 1结构的RNA的化学工具。
T74480	m7GpppCpG	Others	Others
	m7GpppCpG，M7GpppNpG 三核苷酸帽类似物的一种寡核苷酸，作为合成具有 cap 0 或 cap 1 结构的 RNA 的化学工具。
T74295	Cap-dependent endonuclease-IN-22	Others	Others
	Cap-dependent endonuclease-IN-22 是一种 Cap 依赖性内切酶(CEN)抑制剂。
T74478	m7GpppUmpG	Others	Others
	m7GpppUmpG，属于M7GpppNpG三核苷酸帽类似物的一种寡核苷酸，作为化学工具应用于具有cap 0或cap 1结构的RNA的合成。
T74481	m7GpppCmpG	Others	Others
	m7GpppCmpG 是 M7GpppNpG 三核苷酸帽类似物的一种寡核苷酸，用于合成带有 cap 0 或 cap 1 结构的 RNA。
T74294	Cap-dependent endonuclease-IN-12	Others	Others
	Cap-dependent endonuclease-IN-12 (EXP-35) 为一种高效的 Cap 依赖性核酸内切酶(CEN)抑制剂，展现出对H1N1的抑制活性，同时具备低细胞毒性特性。
T37154	7-Methylguanosine 5'-diphosphate sodium	Others	Others
	7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1]. 7-Methylguanosine 5’-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1].T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5’-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2]. [1]. Sonenberg N, et al. Nonspecific effect o...
T74471	m7GpppAmpG	Others	Others
	m7GpppAmpG 是一种三核苷酸 5′ 端帽类似物，对 RNA 的 cap 效率为90%。
T74744	MTX-23	PROTACs	PROTAC
	MTX-23为基于AR的PROTAC, 通过降解AR-V7与AR-FL，抑制CaP细胞增殖，并诱导细胞凋亡(apoptosis)。
T74464	m7GpppApG	Others	Others
	m7GpppApG 是一个三核苷酸，mRNA 5' 帽子的类似物，可以用于体外 RNA 合成。
T74474	m7Gpppm6AmpG ammonium	Others	Others
	m7Gppm6AmpG ammonium 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 的合成。
T74472	m7GpppAmpG ammonium	Others	Others
	m7GpppAmpG ammonium 是一种三核苷酸 5′ 端帽类似物，对 RNA 的加帽率为 90%。
T75264	7-Methyl-guanosine-5'-triphosphate sodium	Others	Others
	7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium 是一种鸟苷 5'-磷酸。7-Methyl-guanosine-5'-triphosphate sodium 的硫代磷酸酯类似物是一种强效的 cap-dependent 翻译抑制剂。
T74135	N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium	Others	Others
	N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium 是体外 RNA 转录中使用的二核苷酸帽类似物。
T74473	m7Gpppm6AmpG	Others	Others
	m7Gppm6AmpG 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 合成。
T76466	CAP 37 (20-44)
	CAP 37 (20-44)是基于CAP37氨基酸残基20-44的肽，属于37 kDa阳离子抗菌蛋白，具有多功能性。
T74476	m7GpppGmpG	Others	Others
	m7GpppGmpG 是一种三核苷酸 5′ 端帽类似物。m7GpppGmpG 对 RNA 的加帽率为 86%。
T37105	2',3'-O-Isopropylideneguanosine	Others	Others
	2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.1...
T74477	m7GpppGmpG ammonium	Others	Others
	m7GpppGmpG ammonium 是一种三核苷酸 5′ 端帽类似物。m7GpppGmpG 对 RNA 的加帽率为 86%。
T82489	eIF4E-IN-6	Others	Others
	eIF4E-IN-6（化合物4b）是一种针对eIF4E设计的抑制剂，可阻止其与cap mRNA的结合，其化学结构为GMP类似物。该化合物在Caco-2、HepG-2和MCF-7细胞系中显示出细胞毒性效果，其IC50值分别约为31、27和21 μM。
T79525	eIF4E-IN-5	Others	Others
	eIF4E-IN-5（Compound 6n）为细胞渗透性eIF4E抑制剂，能与加帽mRNA结合，从而抑制帽依赖性翻译。
T81004	Tetraproline
	Tetraproline是tristetraprolin (TTP)的片段序列，其与4EHP-GYF2帽结合复合物的募集相互作用，这一过程促进了富含AU元件的mRNA的抑制与降解。
T75166	Influenza virus-IN-7	Others	Others
	Influenza virus-IN-7 (Example 16) 是一种口服活性的帽依赖性核酸内切酶抑制剂，适用于流感病毒感染疾病的研究。
T72125	Cap-dependent endonuclease-IN-9	Influenza Virus	Microbiology/Virology
	Cap-dependent endonuclease-IN-9 是高效的 CEN 抑制剂，其对流感病毒具明显抑制作用，同时展现低细胞毒性、良好的体内药剂动力学及药效学特性。此化合物强力抑制 A 病毒 RNA 聚合酶活性。
T74475	m7GpppGpG	Others	Others
	m7GpppGpG 是 M7GpppNpG 三核苷酸帽类似物的一种寡核苷酸。它能够防止 5'-外切核酸酶过早的降解作用，并能够募集前 mRNA 剪接、mRNA 转运以及蛋白质生物合成启动所需的蛋白质。
T36105	coumarin-SAHA coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA	Others	Others
	Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
T74470	3'Ome-m7GpppAmpG ammonium	Others	Others
	3'Ome-m7GpppAmpG ammonium 是一种三核苷酸帽类似物，含锁核酸(LNA)分子，具显著翻译效率。作为潜在的分子生物学工具，3'Ome-m7GpppAmpG ammonium 在mRNA疫苗、mRNA转染领域应用广泛，涵盖蛋白质生产、基因治疗以及抗癌免疫等方面。
T74469	3'Ome-m7GpppAmpG	Others	Others
	3'Ome-m7GpppAmpG为具有锁核酸(LNA)分子的三核苷酸帽类似物，显示出显著的翻译效率。作为mRNA疫苗和mRNA转染领域的潜在分子生物学工具，3'Ome-m7GpppAmpG适用于蛋白质生产、基因治疗和抗癌免疫等应用。

化合物

Cat.No: T71799

Target: Others

Cap-dependent endonuclease-IN-1

Cat.No: T63808

Target: Others

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

Cat.No: T36451

Synonym: 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt),biotin-cap-DPPE

Target: Others

Cap-dependent endonuclease-IN-26

Cat.No: T61757

Target: Others

Cat.No: T74479

Target: Others

Cat.No: T74480

Target: Others

Cap-dependent endonuclease-IN-22

Cat.No: T74295

Target: Others

Cat.No: T74478

Target: Others

Cat.No: T74481

Target: Others

Cap-dependent endonuclease-IN-12

Cat.No: T74294

Target: Others

7-Methylguanosine 5'-diphosphate sodium

Cat.No: T37154

Target: Others

Cat.No: T74471

Target: Others

Cat.No: T74744

Target: PROTACs

Cat.No: T74464

Target: Others

m7Gpppm6AmpG ammonium

Cat.No: T74474

Target: Others

m7GpppAmpG ammonium

Cat.No: T74472

Target: Others

7-Methyl-guanosine-5'-triphosphate sodium

Cat.No: T75264

Target: Others

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium

Cat.No: T74135

Target: Others

Cat.No: T74473

Target: Others

CAP 37 (20-44)

Cat.No: T76466

Cat.No: T74476

Target: Others

2',3'-O-Isopropylideneguanosine

Cat.No: T37105

Target: Others

m7GpppGmpG ammonium

Cat.No: T74477

Target: Others

Cat.No: T82489

Target: Others

Cat.No: T79525

Target: Others

Cat.No: T81004

Influenza virus-IN-7

Cat.No: T75166

Target: Others

Cap-dependent endonuclease-IN-9

Cat.No: T72125

Target: Influenza Virus

Cat.No: T74475

Target: Others

Cat.No: T36105

Synonym: coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA

Target: Others

3'Ome-m7GpppAmpG ammonium

Cat.No: T74470

Target: Others

3'Ome-m7GpppAmpG

Cat.No: T74469

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T36734	Methyl brevifolincarboxylate	Others	Others
	Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2]. Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM. [1]. Wu QY, et al. Chromatographic fingerprint and the simultane...

天然产物

Methyl brevifolincarboxylate

Cat.No: T36734

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0105	Baloxavir-d4
	Baloxavir-d4 是 Baloxavir 的氘代化合物。Baloxavir 的 CAS 号为 1985605-59-1。Baloxavir 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。

同位素

Cat.No: TMIH-0105

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