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Cat. No. Product Name Species Expression System
TMPH-01621 BRCC3 Protein, Human, Recombinant (His & SUMO)

BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/...

Human E. coli
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...
TMPH-01267 RNF13 Protein, Human, Recombinant (His & Myc)

Human E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

BRCC3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01621
Species: Human
Expression System: E. coli
RNF13 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01267
Species: Human
Expression System: E. coli
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