Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18704 |
SPDH
|
Others | Others |
SPDH is a cleavable antibody-drug conjugate (ADC) linker utilized for the diagnosis and therapy of cancer as well as B cell proliferative diseases. | |||
T18717 | SPDV | Others | Others |
SPDV is a cleavable antibody-drug conjugate (ADC) linker utilized in the diagnostic and therapeutic management of cancer and B cell proliferative diseases. | |||
T41146 |
ND1-YL2
ND1-YL2 |
||
ND1-YL2 is a peptide-based PROTAC®Degrader of steroid receptor co-activator 1 (SRC-1; also known as nuclear receptor coactivator 1, NCOA1). ND1-YL2 is composed of a stapled peptide that binds SRC-1 (YL2) joined by a linker to a tetrapeptide that binds UBR box domains. Upon ternary complex formation, SRC-1 is polyubiquitinated and subsequently degraded via the N-degron pathway. This Degrader induces dose-dependent degradation of SRC-1 in the MDA-MB-231 triple negative breast cancer cell line (DC5... |