Cat. No. | Product Name | Target | Signaling Pathways |
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T83003 |
Antitumor agent-40
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Antitumor agent-40为一种抗癌研究用药物。 | |||
T74494 |
Antitumor agent-63
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Antitumor agent-63(Compound 40),一种20 (S)-O-linked camptothecin (CPT) 糖复合物,作为抗肿瘤剂,对正常细胞展现出无毒性。该化合物表现出高稳定性和低topoisomeraseI (Topo I)直接抑制活性。 | |||
T83008 |
Antitumor agent-119
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Antitumor agent-119(化合物13K)为2-苯并恶唑基腙衍生物,显示抗癌活性。该化合物对Butkitt、CCRF-CEM、HeLa和HT-29细胞系展现出细胞生长抑制作用,其IC50值分别为30 nM、140 nM、100 nM和40 nM。 | |||
T36745 |
cDPCP
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cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad... |