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Search Results for " amylin "

26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1232	Amylin, amide, rat Amylin (rat)
	Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac
TP1233	Amylin (8-37), rat Amylin (8-37) (mouse, rat)
	Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin fro
TP1519	Amylin (IAPP), feline
	Amylin (IAPP), feline is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.
T35627	Amylin (human) (trifluoroacetate salt)
	Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cro...
T38764	Amylin (8-37), human
	Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.
TP1183	Amylin, amide, human DAP amide, human
	Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitu
T38764L	Amylin (8-37), human acetate(135702-23-7 free base)
	Amylin (8-37), human acetate(135702-23-7 free base) 源自人 Amylin，对大鼠离体肠系膜阻力动脉具有直接血管舒张作用。 Amylin (8-37), human acetate，是一种小型胰腺 β 细胞激素，在没有胰岛素的情况下会形成聚集体，是 II 型糖尿病的一个关键病理特征。
T76480	Amylin (1-37) (human)
	Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素，其C端经酰胺化处理，第2和第7个半胱氨酸残基间形成二硫键。
T81678	NF(N-Me)GA(N-Me)IL Amylin (22-27) [NMeG24, NMeI26], human (IAPP)
	NF(N-Me)GA(N-Me)IL是一种改性的生物活性肽，对应于人胰岛淀粉样蛋白多肽hIAPP中的22至27氨基酸片段（NFGAIL），其G24和I26的酰胺键经N-甲基化处理。引入N-甲基基团使得原本促进淀粉样蛋白形成及具细胞毒性的序列变为不促进淀粉样蛋白形成和无细胞毒性。此肽可高亲和力结合至全长hIAPP，并有效抑制其纤维化过程。
T76028	Amylin (IAPP), feline TFA
	Amylin (IAPP), feline TFA，一种来自猫科动物、含37个氨基酸的多肽，为胰岛β细胞的主要分泌物之一。作为调节肽，它能够抑制胰岛素和胰高血糖素的分泌。
T75787	Amylin, amide, human TFA
	Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽，与胰岛素共同分泌，对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌，延缓胃排空速度，同时作为增加饱腹感的因子。
T76478	Amylin (8-37) (human)
	Amylin (8-37) (human) (hIAPP (8-37))，为人类胰岛淀粉样多肽(IAPP)第8至第37位氨基酸片段。该片段在组装过程中形成带有发夹结构的双重折叠构型。
T76645	Acetyl-Amylin (8-37) (human)
	Acetyl-Amylin (8-37) (human) 是特异性的 amylin 拮抗剂。
TP2320	Pramlintide acetate(151126-32-8 free base)	Others	Others
	Pramlintide acetate是人源淀粉样肽的多肽类似物。作为一种抗糖尿病药物，它在结直肠癌中展现出抗肿瘤活性。
TP2135L	cAC 253 acetate cAC 253 acetate (TP2135 Free base)	Amylin Receptor	GPCR/G Protein
	cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。
T38998	Pramlintide
	Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.
TP1257	Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)
	Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.
T36911	Pramlintide (acetate hydrate)
	Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and incr...
T76262	Cagrilintide
	Cagrilintide为一种处于研发阶段的新型长效酰化胰岛素类似物，兼具非选择性胰岛素受体(AMYR)与降钙素G蛋白偶联受体(CTR)的激动剂功能。该化合物能显著降低体重并减少食物摄入，展现出针对肥胖疾病的研究潜力。
TP2135	cAC 253
	Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
TP2078	AC 253
	Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks el
T75934	AC 187 TFA
	AC 187 TFA 是一种有效且具有口服活性的胰淀素受体 (amylin receptor) 拮抗剂，IC50为 0.48 nM，Ki 为 0.275 nM。AC 187 TFA 对胰淀素受体的选择性高于降钙素和 CGRP 受体。AC 187 TFA 具有神经保护作用。
T75709	Pramlintide TFA
	Pramlintide TFA，一种人类淀粉样肽类似物，主要作为抗糖尿病药物使用，并可用于肠癌研究。
TP1677	Calcitonin (8-32), salmon
	Calcitonin (8-32), salmon is a highly selective amylin receptor antagonist.Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid g
T36555	Tyr-α-CGRP (human) (trifluoroacetate salt)
	Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated rig...
T37413	Calcitonin (salmon) (trifluoroacetate salt)
	Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin gene-related peptide , and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and ...

化合物

Amylin, amide, rat

Cat.No: TP1232

Synonym: Amylin (rat)

Amylin (8-37), rat

Cat.No: TP1233

Synonym: Amylin (8-37) (mouse, rat)

Amylin (IAPP), feline

Cat.No: TP1519

Amylin (human) (trifluoroacetate salt)

Cat.No: T35627

Amylin (8-37), human

Cat.No: T38764

Amylin, amide, human

Cat.No: TP1183

Synonym: DAP amide, human

Amylin (8-37), human acetate(135702-23-7 free base)

Cat.No: T38764L

Amylin (1-37) (human)

Cat.No: T76480

NF(N-Me)GA(N-Me)IL

Cat.No: T81678

Synonym: Amylin (22-27) [NMeG24, NMeI26], human (IAPP)

Amylin (IAPP), feline TFA

Cat.No: T76028

Amylin, amide, human TFA

Cat.No: T75787

Amylin (8-37) (human)

Cat.No: T76478

Acetyl-Amylin (8-37) (human)

Cat.No: T76645

Pramlintide acetate(151126-32-8 free base)

Cat.No: TP2320

Target: Others

cAC 253 acetate

Cat.No: TP2135L

Synonym: cAC 253 acetate (TP2135 Free base)

Target: Amylin Receptor

Cat.No: T38998

Adrenomedullin (AM) (22-52), human

Cat.No: TP1257

Synonym: 22-52-Adrenomedullin (human)

Pramlintide (acetate hydrate)

Cat.No: T36911

Cat.No: T76262

Cat.No: TP2135

Cat.No: TP2078

Cat.No: T75934

Pramlintide TFA

Cat.No: T75709

Calcitonin (8-32), salmon

Cat.No: TP1677

Tyr-α-CGRP (human) (trifluoroacetate salt)

Cat.No: T36555

Calcitonin (salmon) (trifluoroacetate salt)

Cat.No: T37413

Cat. No.	Product Name	Target	Signaling Pathways
TP1232L	Amylin, amide, rat acetate(124447-81-0,free base)	Amylin Receptor	GPCR/G Protein
	Amylin, amide, rat acetate(124447-81-0,free base) 是 AMY1 和 AMY3 受体以及 AMY2 受体的强效和高亲和力配体。
T21581L	AC 187 Acetate AC 187 Acetate (151804-77-2 Free base)	Amylin Receptor	GPCR/G Protein
	AC 187 Acetate 是胰淀素受体的强效拮抗剂。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。

天然产物

Amylin, amide, rat acetate(124447-81-0,free base)

Cat.No: TP1232L

Target: Amylin Receptor

Cat.No: T21581L

Synonym: AC 187 Acetate (151804-77-2 Free base)

Target: Amylin Receptor

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