Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00870 |
AREG Protein, Mouse, Recombinant (hFc)
AR,MGC13647,CRDGF,AREG,Amphiregulin,SDGF,AREGB |
Mouse | HEK293 Cells |
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. | |||
TMPK-00820 |
AREG Protein, Human, Recombinant (hFc)
SDGF,AR,MGC13647,AREGB,CRDGF,Amphiregulin,AREG |
Human | HEK293 Cells |
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic cancer. AREG may play a critical role in cell migration, invasion, and EMT by activating the EGFR/ERK/NF‑κB signalling pathway in pancreatic cancer cells. | |||
TMPJ-00859 |
AREG Protein, Human, Recombinant
AR,CRDGF,Amphiregulin,Colorectum Cell-Derived Growt... |
Human | E. coli |
Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits... | |||
TMPJ-00058 |
BTC Protein, Mouse, Recombinant (His)
βcellulin,isoform CRA_a,Btc,Betacellulin,mCG_12529 |
Mouse | E. coli |
Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine.... |