4
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9345 |
Aminopeptidase M
|
Others | Others |
Aminopeptidase M 抑制对多种疾病(例如高度血管化的癌症类型)具有重要意义。 | |||
T25987 | Probestin | ||
Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6. | |||
T32676 |
Leucylmethionine
Leu-met |
||
Leucylmethionine is a substrate for aminopeptidase M. | |||
T37062 |
L-Leucine-7-amido-4-methylcoumarin hydrochloride
|
||
L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometryS... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. |