Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01399 |
ASF1A Protein, Human, Recombinant (His, T7)
CIA,Anti-Silencing Function Protein 1 Homolog A,ASF... |
Human | E. coli |
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chromatin Assembly Factor 1 to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. In addition, ASF1A is necessary for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associat... | |||
TMPY-03341 |
ASF1B Protein, Human, Recombinant (His)
anti-silencing function 1B histone chaperone,CIA-II |
Human | Baculovirus Insect Cells |
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely... |