Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00870 |
AREG Protein, Mouse, Recombinant (hFc)
AR,MGC13647,CRDGF,AREG,Amphiregulin,SDGF,AREG |
Mouse | HEK293 Cells |
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. | |||
TMPK-00820 |
AREG Protein, Human, Recombinant (hFc)
SDGF,AR,MGC13647,AREGB,CRDGF,Amphiregulin,AREG<... |
Human | HEK293 Cells |
Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family and is expressed in a plethora of cancers. Tumour growth and metastasis were decreased by AREG silencing in an orthotopic model of pancreatic cancer. AREG may play a critical role in cell migration, invasion, and EMT by activating the EGFR/ERK/NF‑κB signalling pathway in pancreatic cancer cells. | |||
TMPJ-00859 |
AREG Protein, Human, Recombinant
AR,CRDGF,Amphiregulin,Colorectum Cell-Derived Growth Factor,... |
Human | E. coli |
Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits... |