Cat. No. | Product Name | Target | Signaling Pathways |
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T39896 |
ALK-IN-9
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ALK-IN-9 (compound 40) is a highly effective ALK inhibitor. It demonstrates remarkable inhibitory activity against cell proliferation, with IC50 values of <0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), and KG-l cell (OP2-FGFR1). | |||
T64051 | ALK5-IN-9 | ||
ALK5-IN-9 是一种有效的、口服具有活力的 TGFβRI (ALK5) 抑制剂。ALK5-IN-9 能够抑制 ALK5 自磷酸化 (IC50: 25 nM) 并抑制 NIH3T3 细胞活性 (IC50: 74.6 nM)。ALK5-IN-9 具有良好的药代动力学特征,能够改善 hERG 抑制。ALK5-IN-9 对癌症疾病表现出研究潜能。 | |||
T37585 | Ensartinib | ||
Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N... |