Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02622 |
Aldolase B Protein, Human, Recombinant (GST)
aldolase B, fructose-bisphosphate,ALDO2,ALDB |
Human | E. coli |
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or... |