Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04770 |
RIOK1 Protein, Human, Recombinant (His & GST)
AD034,RRP10,bA288G3.1,RIO kinase 1 |
Human | Baculovirus Insect Cells |
RIOK1, also known as RIO kinase 1, is a member of the RIO family of atypical serine protein kinases first characterized in yeast. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. RIOK1 functions as a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. RioK1 and pICln bind to PRMT5 in a mutually exclusive fashion. This results in a PRMT5-WD45/MEP5 core structure ... |