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Cat. No.	Product Name	Target	Signaling Pathways
T26412	A 274 A-274,A274
	A 274 is a highly aromatic, monosubstituted phenol antioxidant generated during differentiation of neuroblastoma cells.
T71974	ABI-274
	ABI-274 is a novel potent colchicine binding site inhibitor (CBSI) and tubulin inhibitor.
T39916	GNE-274
	GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.
T71250	NCX-274
	NCX-274 is a ROCK inhibitor and NO-donating anti-glaucoma agent
T79032	Enpp-1-IN-17
	Enpp-1-IN-17 (example 274) 是一种ENPP1抑制剂，其对cGAMP水解的Ki值在100 nM-1 μM范围内，而对ATP水解的Ki值则大于1 μM。该化合物在抑制cGAMP水解方面相对于ATP水解的选择性比率超过6.4。
T36974	D-threo-PPMP hydrochloride
	D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201...