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Cat. No. Product Name Target Signaling Pathways
T61283 Topoisomerase II inhibitor 3

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].

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Topoisomerase II inhibitor 3
Cat.No: T61283
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