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Cat. No. Product Name Target Signaling Pathways
T36161 8-iso Prostaglandin E2 isopropyl ester

8-iso Prostaglandin E2 isopropyl ester

8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.
T36160 8-iso Prostaglandin E2

8-iso Prostaglandin E2

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
T36168 8-iso-16-cyclohexyl-tetranor Prostaglandin E2

8-iso-16-cyclohexyl-tetranor Prostaglandin E2

8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no published studies on the pharmacological properties of 8-iso-16-cyclohexyl-tetranor PGE2.
T35991 ent-Prostaglandin E2

ent-Prostaglandin E2

Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), g...

化合物

8-iso Prostaglandin E2 isopropyl ester
Cat.No: T36161
Synonym: 8-iso Prostaglandin E2 isopropyl ester
Target:
8-iso Prostaglandin E2
Cat.No: T36160
Synonym: 8-iso Prostaglandin E2
Target:
8-iso-16-cyclohexyl-tetranor Prostaglandin E2
Cat.No: T36168
Synonym: 8-iso-16-cyclohexyl-tetranor Prostaglandin E2
Target:
ent-Prostaglandin E2
Cat.No: T35991
Synonym: ent-Prostaglandin E2
Target:
TargetMol Loading
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