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Cat. No. Product Name Target Signaling Pathways
T36998 7β,27-dihydroxy Cholesterol

7β,27-DHC,7β,27-dihydroxy Cholesterol

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...

化合物

7β,27-dihydroxy Cholesterol
Cat.No: T36998
Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol
Target:
TargetMol Loading
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