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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T71562	Boxidine
	Boxidine inhibits the transformation of 7-dehydrocholesterol to cholesterol & also inhibits sterol absorption.
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which...
T10167	5-Dehydroepisterol	Others	Others
	5-Dehydroepisterol is an episterol derivative with anti-fungal activities. It can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase.
T74208	Pyrocholecalciferol
	Pyrocholecalciferol 一种维生素 D 类似物，由 7-脱氢胆固醇 (7-DHC) 的光化学转化产生。
T70151	MeTC7
	MeTC7 is a VDR antagonist, which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.
T82853	BM 15766 sulfate
	BM 15766 sulfate是一种7-脱氢胆固醇δ7-还原酶的抑制剂，具有降低血浆胆固醇水平的作用，属于降血脂剂类药物。

化合物

Cat. No.	Product Name	Target	Signaling Pathways
T4923	7-Dehydrocholesterol Provitamin D3,7-DHC,7-去氢胆固醇	Endogenous Metabolite	Metabolism
	7-Dehydrocholesterol (Provitamin D3) 是合成胆固醇和维生素 D3的前体。7-Dehydrocholesterol 下调培养的 Smith-Lemi-Opitz 综合征皮肤成纤维细胞中的胆固醇生物合成。