Cat. No. | Product Name | Target | Signaling Pathways |
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T23239 |
Ro 04-5595 hydrochloride
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Others | Others |
NR2B-containing NMDA receptors antagonist | |||
T70049 |
Ro 04-5595 free base
|
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Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and... |