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Cat. No. Product Name Target Signaling Pathways
T37699 Org 24598

Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibi...
T37700 Org 24598 lithium salt

Org 24598 lithium salt 是一种甘氨酸转运蛋白1 GlyT-1 抑制剂。Org 24598 lithium salt 可以抑制 [3H]CHIBA-3007 与大鼠体内脑膜的特异性结合(Ki=16.9 nM)。

化合物

Org 24598
Cat.No: T37699
Synonym:
Target:
Org 24598 lithium salt
Cat.No: T37700
Synonym:
Target:
TargetMol Loading
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