Cat. No. | Product Name | Target | Signaling Pathways |
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T38841 |
IRE1α kinase-IN-2
IRE1α kinase-IN-2 |
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IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines. |