Cat. No. | Product Name | Target | Signaling Pathways |
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T35526 |
PI3-Kinase α Inhibitor 2 (hydrochloride)
PI3-Kinase α Inhibitor 2 (hydrochloride) |
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PI3-Kinase α Inhibitor 2 (hydrochloride) 是一种 PI3-Kinase α 抑制剂。 | |||
T35525 |
PI3-Kinase α Inhibitor 2
PI3-Kinase α Inhibitor 2 |
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Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It... |