Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17164 |
Trimetrexate
三甲曲沙,CI-898 |
Others | Others |
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. | |||
T63985 |
Trimetrexate glucuronate
|
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Trimetrexate glucuronate (NSC 352122) 是一种叶酸拮抗剂,能够抑制二氢叶酸还原酶 (dihydrofolate reductase),进而阻断嘌呤核苷酸和胸苷酸的合成,影响 DNA 和 RNA 合成,表现出潜在的抗肿瘤效果。 | |||
T70304 |
CI-898 HCl
|
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CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia. |