Cat. No. | Product Name | Target | Signaling Pathways |
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TP1226 |
β-Amyloid (1-28)
Amyloid β-Protein (1-28),β-Amyloid 1-28 |
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β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. | |||
T80037 |
5-FAM-β-Amyloid (1-28)
5-FAM-Amyloid β-protein (1-28) |
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5-FAM-β-Amyloid (1-28) 为β-Amyloid (1-28) 分子的荧光标记形式。 | |||
T75779 |
β-Amyloid (12-28) (TFA)
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β-Amyloid (12-28) (TFA)为β-淀粉样蛋白(β1-42)的肽片段,后者是由42个氨基酸组成,构成老年斑核心的关键蛋白。β-Amyloid (12-28) (TFA)展现出聚集性质,并可能对阿尔茨海默氏病研究具有潜在价值。 | |||
T80700 |
β Amyloid(17-28) human
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β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段,其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集,导致阿尔茨海默病(AD)中具毒性的聚集体形成。 | |||
T80699 |
β Amyloid(28-35) human
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β Amyloid(28-35) human 是一种具有神经毒性的β-淀粉样肽,能够与神经元膜结合,影响其二级结构并加剧阿尔茨海默病的神经毒性。该肽段对酸性磷脂DPH表现出非均向性作用,从而增加脂质膜双层内部的流动性。该核心片段由脂质诱导形成。 | |||
T36911 |
Pramlintide (acetate hydrate)
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Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and incr... |