Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IMD-0560 是新型 IκB kinase β抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 732 | 现货 | ||
5 mg | ¥ 1,830 | 现货 | ||
10 mg | ¥ 2,890 | 现货 | ||
25 mg | ¥ 4,890 | 现货 | ||
50 mg | ¥ 6,980 | 现货 | ||
100 mg | ¥ 9,420 | 现货 |
产品描述 | IMD-0560 is a novel inhibitor of IκB kinase β. |
体外活性 | IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. |
体内活性 | Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group. |
分子量 | 428.12 |
分子式 | C15H8BrF6NO2 |
CAS No. | 439144-66-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 50 mg/mL (116.79 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol | 1 mM | 2.3358 mL | 11.679 mL | 23.3579 mL | 58.3948 mL |
5 mM | 0.4672 mL | 2.3358 mL | 4.6716 mL | 11.679 mL | |
10 mM | 0.2336 mL | 1.1679 mL | 2.3358 mL | 5.8395 mL | |
20 mM | 0.1168 mL | 0.5839 mL | 1.1679 mL | 2.9197 mL | |
50 mM | 0.0467 mL | 0.2336 mL | 0.4672 mL | 1.1679 mL | |
100 mM | 0.0234 mL | 0.1168 mL | 0.2336 mL | 0.5839 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
IMD-0560 439144-66-8 NF-Κb IκB/IKK inhibit I kappa B kinase Inhibitor IMD 0560 IκB kinase IMD0560 IKK inhibitor