Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acitretin (Ro 10-1670) 是一种维甲酸,可用于银屑病和阿尔兹海默症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 268 | 现货 | ||
25 mg | ¥ 413 | 现货 | ||
50 mg | ¥ 641 | 现货 | ||
100 mg | ¥ 983 | 现货 | ||
200 mg | ¥ 1,516 | 现货 | ||
500 mg | ¥ 2,396 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 288 | 现货 |
产品描述 | Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. |
体外活性 | Acitretin stimulates ADAM10 promoter activity with an EC(50) of 1.5 mM and leads to an increase of mature ADAM10 protein that results in a two- to three-fold increase of the ratio between alpha- and beta-secretase activity in neuroblastoma cells. [1] Acitretin (5-20 μM) impairs mitochondrial phosphorylation efficiency as demonstrated by the decrease in the state 3 respiration and ATP levels, and by the increase in the lag phase of ADP phosphorylation cycle, without affecting the membrane potential. Acitretin induces Ca(2+)-mediated mitochondrial permeability transition (MPT) and decreased the adenine nucleotide translocase (ANT) content. [2] Acitretin preferentially inhibits the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. Acitretin increases the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte. [3] |
体内活性 | Acitretin undergoes alpha-oxidation, chain shortening O-demethylation, and glucuronidation in the perfused rat liver. [4] Acitretin rapidly appears in liver and muscle of rats, where it undergoes redistribution into skin and adipose tissue. [5] |
别名 | 阿曲汀, Ro 10-1670, Etretin |
分子量 | 326.43 |
分子式 | C21H26O3 |
CAS No. | 55079-83-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 16 mg/mL (49 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0634 mL | 15.3172 mL | 30.6344 mL | 76.5861 mL |
5 mM | 0.6127 mL | 3.0634 mL | 6.1269 mL | 15.3172 mL | |
10 mM | 0.3063 mL | 1.5317 mL | 3.0634 mL | 7.6586 mL | |
20 mM | 0.1532 mL | 0.7659 mL | 1.5317 mL | 3.8293 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Acitretin 55079-83-9 Apoptosis Autophagy Metabolism Retinoid Receptor inhibit 阿曲汀 Retinoic acid receptors Ro 10-1670 RAR/RXR Retinoid X receptors Inhibitor Etretin inhibitor