Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Traxoprodil (CP101606) 是一种有效的和选择性的NMDA 拮抗剂,能够保护海马神经元,其 IC50=10 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 247 | 现货 | ||
2 mg | ¥ 359 | 现货 | ||
5 mg | ¥ 621 | 现货 | ||
10 mg | ¥ 913 | 现货 | ||
25 mg | ¥ 1,990 | 现货 | ||
50 mg | ¥ 3,260 | 现货 | ||
100 mg | ¥ 4,770 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 683 | 现货 |
产品描述 | Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). |
靶点活性 | NMDA Receptor:10 nM |
体内活性 | Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (i.p.) stimulated c-fos induction in mice [1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the forced swim test and it is not related to changes in animals’ locomotor activity [2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures and decreases the total time spent in seizures [3]. |
动物实验 | The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2]. |
别名 | 曲索罗地, CP101606 |
分子量 | 327.42 |
分子式 | C20H25NO3 |
CAS No. | 134234-12-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 62.5 mg/mL (190.89 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0542 mL | 15.2709 mL | 30.5418 mL | 76.3545 mL |
5 mM | 0.6108 mL | 3.0542 mL | 6.1084 mL | 15.2709 mL | |
10 mM | 0.3054 mL | 1.5271 mL | 3.0542 mL | 7.6355 mL | |
20 mM | 0.1527 mL | 0.7635 mL | 1.5271 mL | 3.8177 mL | |
50 mM | 0.0611 mL | 0.3054 mL | 0.6108 mL | 1.5271 mL | |
100 mM | 0.0305 mL | 0.1527 mL | 0.3054 mL | 0.7635 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Traxoprodil 134234-12-1 Membrane transporter/Ion channel Neuroscience NMDAR iGluR Ionotropic glutamate receptors CP-101606 inhibit 曲索罗地 CP 101606 Inhibitor CP101606 inhibitor