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Omberacetam

产品编号 T7108 CAS 157115-85-0

别名: SGS-111, Noopept, GVS-111

Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽，有促智和提高认知作用。

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Omberacetam, CAS 157115-85-0

规格	价格/CNY	货期
2 mg	￥ 198	现货
5 mg	￥ 328	现货
10 mg	￥ 528	现货
25 mg	￥ 1,060	现货
50 mg	￥ 1,730	现货
100 mg	￥ 2,660	现货
200 mg	￥ 3,890	现货
500 mg	￥ 6,170	现货
1 mL * 10 mM (in DMSO)	￥ 363	现货

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纯度: 98%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
体外活性	The neuroprotective effect of noopept (added to the medium at 10 μM concentration, 72 hours before Аβ 25-35) was studied on Аβ 25-35-induced injury (5 μM for 24 h) in PC12 cells.?The ability of drug to protect the impairments of cell viability, calcium homeostasis, ROS level, mitochondrial function, tau phosphorylation and neurite outgrowth caused by Аβ 25-35 were evaluated.?Following the exposure of PC12 cells to Аβ 25-35 an increase of the level of ROS, intracellular calcium, and tau phosphorylation at Ser396 were observed;?these changes were accompanied by a decrease in cell viability and an increase of apoptosis.?Noopept treatment before the amyloid-beta exposure improved PC12 cells viability, reduced the number of early and late apoptotic cells, the levels of intracellular reactive oxygen species and calcium and enhanced the mitochondrial membrane potential.?In addition, pretreatment of PC12 cell with noopept significantly attenuated tau hyperphosphorylation at Ser396 and ameliorated the alterations of neurite outgrowth evoked by Аβ25-35[1].
体内活性	Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals[2].
细胞实验	PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1].
动物实验	Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2].

别名	SGS-111, Noopept, GVS-111
分子量	318.37
分子式	C17H22N2O4
CAS No.	157115-85-0

存储

keep away from moisture　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 100 mg/mL (314.10 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.141 mL	15.705 mL	31.41 mL	78.525 mL
	5 mM	0.6282 mL	3.141 mL	6.282 mL	15.705 mL
	10 mM	0.3141 mL	1.5705 mL	3.141 mL	7.8525 mL
	20 mM	0.157 mL	0.7852 mL	1.5705 mL	3.9262 mL
	50 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5705 mL
	100 mM	0.0314 mL	0.157 mL	0.3141 mL	0.7852 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

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配液浓度

参考文献

1. Ostrovskaya R U , Vakhitova Y V , Uliyana Sh Kuzmina…. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation[J]. Journal of Biomedical Science, 2014, 21(1). 2. Uyanaev A A , Fisenko V P . Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis[J]. Bulletin of Experimental Biology & Medicine, 2006, 142(2):202-204.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Omberacetam 157115-85-0 Membrane transporter/Ion channel Neuroscience Others iGluR Inhibitor SGS-111 Ionotropic glutamate receptors Noopept GVS 111 inhibit SGS 111 GVS111 GVS-111 SGS111 inhibitor

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Omberacetam

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords