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Farampator

Farampator

产品编号 T3957   CAS 211735-76-1
别名: Org24448, CX-691

Farampator (CX-691) 是 AMPA 受体正调节剂。

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Farampator Chemical Structure
Farampator, CAS 211735-76-1
规格 价格/CNY 货期 数量
1 mg ¥ 298 现货
2 mg ¥ 428 现货
5 mg ¥ 729 现货
10 mg ¥ 980 现货
25 mg ¥ 1,980 现货
50 mg ¥ 3,320 现货
100 mg ¥ 4,880 现货
500 mg ¥ 9,870 现货
1 mL * 10 mM (in DMSO) ¥ 803 现货
产品目录号及名称: Farampator (T3957)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.
体外活性 CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.). Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs. Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia.
体内活性 Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.)[1]. Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Besides, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs[2].
别名 Org24448, CX-691
分子量 231.25
分子式 C12H13N3O2
CAS No. 211735-76-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 50 mg/mL (216.21 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3243 mL 21.6216 mL 43.2432 mL 108.1081 mL
5 mM 0.8649 mL 4.3243 mL 8.6486 mL 21.6216 mL
10 mM 0.4324 mL 2.1622 mL 4.3243 mL 10.8108 mL
20 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4054 mL
50 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
100 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Woolley ML, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. 2. Wezenberg E, et al. Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83.
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相关化合物库

该产品包含在如下化合物库中:
神经退行性疾病化合物库 抗癌药物库 抗癌临床化合物库 经典已知活性库 抗阿尔茨海默症化合物库 抗癌化合物库 神经信号分子库 表型筛选靶点鉴定库 抗抑郁症化合物库 药物功能重定位化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Farampator 211735-76-1 Membrane transporter/Ion channel Neuroscience GluR iGluR inhibit Org 24448 Org-24448 Org24448 Inhibitor CX 691 CX691 Ionotropic glutamate receptors CX-691 inhibitor

 

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