Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulmazole (AR-L 115-BS) 是一种小分子 cGMP-PDE抑制剂。Sulmazole 对 A1 腺苷受体具有竞争性抑制作用,可改善心脏指数,低肺毛细血管楔压,可用于研究心脏衰竭。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 223 | 现货 | ||
5 mg | ¥ 498 | 现货 | ||
10 mg | ¥ 742 | 现货 | ||
25 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,860 | 现货 | ||
100 mg | ¥ 2,770 | 现货 | ||
500 mg | ¥ 6,580 | 现货 |
产品描述 | Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor. |
体外活性 | In cell-free biochemical assays, observed activities of sulmazole are cyclic nucleotide phosphodiesterase inhibitors with similar potencies and selectivities for the Type III enzyme (IC50=5.0 +/- 1.9 X 10(-5) M). sulmazole had little or no effects on sarcolemmal Na+/K+-ATPase, Ca2+ ATPase or Na+/Ca2+ exchange, and sulmazole had a small, stimulatory effect on myofibrillar ATPase.[2] |
体内活性 | In anaesthetized guinea pigs and dogs, bolus i.v. injections of sulmazole (0.1-10.0 mg kg-1) caused a significant, dose-related increase in ventricular dP/dt, and a reduction in diastolic blood pressure, with small increases in heart rate.[1] |
别名 | Vardax, AR-L 115BS, AR-L 115-BS |
分子量 | 287.34 |
分子式 | C14H13N3O2S |
CAS No. | 73384-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sulmazole 73384-60-8 GPCR/G Protein Metabolism Microbiology/Virology Neuroscience PDE Parasite Adenosine Receptor Vardax AR-L 115BS AR-L 115-BS Inhibitor inhibitor inhibit