Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Suprofen (Suprol) 是一种非甾体抗炎化合物,对前列腺素合成具有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 172 | 现货 | ||
5 mg | ¥ 378 | 现货 | ||
10 mg | ¥ 622 | 现货 | ||
25 mg | ¥ 1,170 | 现货 | ||
50 mg | ¥ 1,930 | 现货 | ||
100 mg | ¥ 3,730 | 现货 | ||
500 mg | ¥ 8,420 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 413 | 现货 |
产品描述 | Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. |
体外活性 | Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4] |
体内活性 | Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. [5] Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. [6] Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization. [7] |
别名 | Maldocil, Suprol, TN-762, 舒洛芬, Profenal |
分子量 | 260.31 |
分子式 | C14H12O3S |
CAS No. | 40828-46-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL(184.4 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.8416 mL | 19.2079 mL | 38.4157 mL | 96.0393 mL |
5 mM | 0.7683 mL | 3.8416 mL | 7.6831 mL | 19.2079 mL | |
10 mM | 0.3842 mL | 1.9208 mL | 3.8416 mL | 9.6039 mL | |
20 mM | 0.1921 mL | 0.9604 mL | 1.9208 mL | 4.802 mL | |
50 mM | 0.0768 mL | 0.3842 mL | 0.7683 mL | 1.9208 mL | |
100 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9604 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Suprofen 40828-46-4 Immunology/Inflammation Neuroscience COX PGE Synthase Maldocil inhibit TN 762 Suprol TN762 TN-762 舒洛芬 Prostaglandin E synthase PGE synthase Profenal Inhibitor inhibitor