Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isomazole 是一种可口服的具有钙敏特性的新型磷酸二酯酶(PDE)抑制剂,对PDE3 和 PDE4 有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 990 | 现货 | ||
5 mg | ¥ 2,470 | 现货 | ||
10 mg | ¥ 3,700 | 现货 | ||
25 mg | ¥ 5,970 | 现货 | ||
50 mg | ¥ 8,260 | 现货 | ||
100 mg | ¥ 10,900 | 现货 | ||
500 mg | ¥ 22,300 | 现货 |
产品描述 | Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4. |
体内活性 | Isomazole (10 and 20 micrograms/kg/min; ) to 10 awake dogs with right-sided congestive heart failure produced by pulmonary artery constriction and tricuspid valve avulsion found that increased cardiac output, heart rate, right ventricular and left ventricular (LV) dP/dt, LVdP/dt/P and decreased aortic pressure and total peripheral vascular resistance. Simultaneously, blood flow increased to myocardium, quadriceps muscle, brain and splanchnic beds, whereas vascular resistance decreased. Furthermore, Isomazole increased LV oxygen consumption and decreased trans-coronary arteriovenous oxygen difference. Angiotensin II was infused to restore mean aortic pressure to base-line values during Isomazole infusion; however, despite the return of aortic pressure to base-line values, cardiac output, LVdP/dt, and LVdP/dt/P remained elevated. The systemic and regional hemodynamic effects of Isomazole were unaffected by pretreatment with propranolol and mecamylamine. Thus, Isomazole exerted positive inotropic, chronotropic, and vasodilator effects in congestive heart failure dogs. The inotropic effect of Isomazole was independent of the decrease in aortic pressure, and the hemodynamic effects of Isomazole were not mediated via the autonomic nervous system. Furthermore, the decrease in trans-coronary arteriovenous oxygen difference suggests that Isomazole exerted an active coronary vasodilator action which may improve the myocardial oxygen demand/supply ratio.[2] |
分子量 | 287.34 |
分子式 | C14H13N3O2S |
CAS No. | 86315-52-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Isomazole 86315-52-8 Metabolism PDE Inhibitor inhibitor inhibit