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5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin

产品编号 TN3110   CAS 7380-39-4

5-Geranoxy-7-methoxycoumarin 是一种香豆素。它诱导细胞凋亡,具有抗癌、抗真菌和抗菌活性。

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5-Geranoxy-7-methoxycoumarin Chemical Structure
5-Geranoxy-7-methoxycoumarin, CAS 7380-39-4
规格 价格/CNY 货期 数量
1 mg ¥ 628 现货
5 mg ¥ 1,530 现货
10 mg ¥ 2,280 现货
25 mg ¥ 3,860 现货
50 mg ¥ 5,530 现货
100 mg ¥ 7,730 现货
1 mL * 10 mM (in DMSO) ¥ 1,620 现货
产品目录号及名称: 5-Geranoxy-7-methoxycoumarin (TN3110)
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纯度: 99.99%
纯度: 99.99%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
植物来源
结构类型
产品描述 5-Geranoxy-7-methoxycoumarin shows antifungal activity.
体外活性 Two mechanisms of the resistance of citrus fruits against pathogens-preformed and induced antifungal materials-were investigated. METHODS AND RESULTS: Flavedo tissue of lemon contains the following preformed antifungal materials: citral, limettin, 5-Geranoxy-7-methoxycoumarin, and isopimpinellin, which act as the first line of defense against pathogens. Exogenous application of citral to Penicillium-inoculated lemon fruit prevented development of decay. Being subjected to fungal challenge and/or abiotic stress, citrus fruits are elicited to produce the phytoalexin scoparone, considered as another line of fruit defense. According to median effective dose (ED50) of the inhibition of germ-tube elongation or percent germination, scoparone had higher fungitoxicity against Penicillium digitatum Sacc. than the preformed antifungal materials. Different citrus species (lemon, orange, grapefruit, lime, kumquat) varied in their capacities to produce scoparone responding to the combined Penicillium inoculation and heat treatment or to UV illumination. UV illumination of lemon fruit reduced its susceptibility to P. digitatum. CONCLUSIONS: Expression of this effect was directly related to the level of scoparone in illuminated fruit. UV light and citral application were visibly injurious to the flavedo tissues in high dose.
分子量 328.4
分子式 C20H24O4
CAS No. 7380-39-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 3.28 mg/mL (10 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0451 mL 15.2253 mL 30.4507 mL 76.1267 mL
5 mM 0.609 mL 3.0451 mL 6.0901 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 7.6127 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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参考文献

1. Preformed and induced antifungal materials of citrus fruits in relation to the enhancement of decay resistance by heat and ultraviolet treatments. Journal of Agricultural and Food Chemistry, 1992, 40(7):1217-1221.

文献引用

1. Li S, Kelly C, Knob R, et al.Analysis of Coumarin-Based Phototoxins in Citrus-Derived Essential Oils Using Liquid Chromatography-Mass Spectrometry.Chromatographia.2023: 1-11.
pimpinellin 2'-Hydroxy-4'-methylacetophenone Dictamine Eriodictyol chalcone Rubiadin-1-methyl ether 2-Furoic acid paulownin Baicalin methyl ester

相关化合物库

该产品包含在如下化合物库中:
抗癌活性化合物库 抗癌化合物库 Ro5类药天然产物库 抗感染天然产物库 人代谢物化合物库 天然产物库 NO PAINS 化合物库 已知活性化合物库 抗真菌库 抗菌活性库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

5-Geranoxy-7-methoxycoumarin 7380-39-4 Microbiology/Virology Anti-infection Antibacterial Antifungal Apoptosis 5 Geranoxy 7 methoxycoumarin Bacterial Fungal antifungal inhibit DNA fragmentation 5Geranoxy7methoxycoumarin Inhibitor inhibitor

 

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